The Effects of Prolonged Sitting on Arterial Stiffness and Circulating Angiogenic Cells in Healthy Adults Public Deposited

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Last Modified
  • March 21, 2019
Creator
  • Evans, William
    • Affiliation: College of Arts and Sciences, Department of Exercise and Sport Science
Abstract
  • To assess the effects of prolonged sitting on measures of arterial stiffness (AS) and circulating angiogenic cells (CAC), healthy but sedentary subjects completed 3 hours of sitting in a randomized crossover design with 10 calf raises every ten minutes (CALF) or a control condition (CON). Pulse wave velocity (PWV) and pulse wave analysis (PWA) and blood draws were performed pre and post to assess AS. CACs were isolated from venous blood for analysis. PWV significantly increased (Mean Difference [MD]0.30 m/s (0.46), p<0.01) and augmentation index (AIx) from PWA significantly decreased from pre-to post (MD=-9.14% (11.09), p<0.001). There was no significant change in CAC counts per 500,000 events or gene expression in either condition across time. In conclusion, aortic AS increases during sitting despite decreases in arterial wave reflection, and local changes observed previously with physical activity do not persist systemically.
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Rights statement
  • In Copyright
Advisor
  • Hanson, Erik
  • Stoner, Lee
  • Creduer, Daniel
Degree
  • Master of Arts
Degree granting institution
  • University of North Carolina at Chapel Hill Graduate School
Graduation year
  • 2018
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