The Role of Plexin-B2 in the Immune System Public Deposited

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Last Modified
  • March 22, 2019
Creator
  • Roney, Kelly E.
    • Affiliation: School of Medicine, Department of Microbiology and Immunology
Abstract
  • Plexins and semaphorins are a family of transmembrane proteins that mediate diverse roles such as cell-cell contact, cell adhesion, cell movement, and cell response. Plexins and semaphorins are unique from other proteins in containing a conserved extracellular semaphorin domain. Semaphorins are smaller than plexins and have short intracellular tails. Plexins are larger and have long intracellular tails that are involved in intracellular signaling. The majority of plexin and semaphorin research has focused on the nervous system since their discovery in the late 1980's. Recently plexins and semaphorins were discovered in the immune system, where they play similar roles similar to those of the nervous system for cell guidance. However, the receptor ligand pairs for semaphorins and plexins in immune system are distinct from those in the nervous system, and plexins and semaphorins have been found to mediate many immune specific cell processes including T cell activation and cytokine response. The B subfamily of plexins has been found to mediate cell movement through activation and deactivation of the Rho family of small GTPases. The majority of B family plexin studies have focused on Plexin-B1 in cell lines or the nervous system. The data in this thesis show that Plexin-B2, and understudied B family plexin, is expressed on cells of the innate immune system in-vivo. Plexin-B2 regulates cell velocity, activation of Rho family members Cdc42 and Rac, and cytokine secretion in macrophages and dendritic cells.
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  • In Copyright
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  • ... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Microbiology and Immunology, School of Medicine.
Advisor
  • Ting, Jenny P.-Y.
Degree granting institution
  • University of North Carolina at Chapel Hill
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