Effects of food availability and administration of orexigenic and anorectic agents on elevated ethanol drinking associated with drinking in the dark procedures Public Deposited

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  • March 20, 2019
  • Lyons, Angela Maria
    • Affiliation: College of Arts and Sciences, Department of Psychology and Neuroscience
  • Drinking in the dark (DID) procedures have recently been developed to induce high levels of ethanol drinking in C57BL/6J mice, which result in blood ethanol concentrations reaching levels that have measurable affects on physiology and/or behavior. The present study determined if increased ethanol drinking associated with DID procedures may be motivated by caloric need rather than by the post-ingestive pharmacological effects of ethanol. To this end, a) the effects of food deprivation on ethanol consumption during DID procedures was assessed, or b) mice were given intraperitoneal injection of the orexigenic peptide ghrelin or the anorectic protein leptin before DID procedures. Neither food deprivation nor administration of orexigenic or anorectic compounds significantly altered ethanol drinking with DID procedures. The present observations are inconsistent with the hypothesis that C57BL/6J mice consume large amounts of ethanol during DID procedures in order to satisfy a caloric need.
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  • Thiele, Todd
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