Local and systemic inflammatory responses in gingivitis subjects: clinical trial of topical triclosan

Local and systemic inflammatory responses in gingivitis subjects: clinical trial of topical triclosan Public Deposited

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McKenzie, Sheppard Allen, IV
- Affiliation: School of Dentistry, Department of Periodontology

Abstract

The objectives of this randomized clinical trial (RCT) were to evaluate the local pharmacodynamic effects of triclosan dentifrice on GCF concentrations of inflammatory mediators in subjects with moderate plaque-induced gingivitis, and to measure systemic inflammatory mediators and document trends in levels. Gingivitis subjects were randomized for: 1)triclosan dentifrice; 2)placebo bid over four weeks. GCF analyses of inflammatory mediators were performed on days 1, 8, 15, 22 and 29 (pre-dosing and post-dosing). Serum analyses of inflammatory mediators were performed each visit. IL- 1β levels were significantly suppressed in the triclosan group short-term. The data indicate consistent short term reductions in local inflammatory mediators when using the triclosan dentifrice (in particular IL-1β and Rank-L (p<0.05). There were no differences in levels of serum inflammatory mediators over the course of 29 days. Nevertheless, the levels of CRP in this population were elevated to the range that confers moderate risk for future cardiovascular disease.

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