STUDY OF DISABLED ADAPTOR PROTEIN IN THE ABELSON KINASE SIGNALING PATHWAY IN DROSOPHILA Public Deposited

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  • March 19, 2019
Creator
  • Kotlyanskaya, Lyudmila
    • Affiliation: School of Medicine, UNC Neuroscience Center, Neuroscience Curriculum
Abstract
  • In the development of tissues such as the nervous system, the actin cytoskeleton is remodeled in cells by protein signaling cascades that allow cells to change shape, move and sense their environment by sending out projections. At the center of one such signaling cascade, important during neuronal migration and axon guidance in both vertebrates and invertebrates, is the Abelson tyrosine kinase. Abl interacts with a set of receptors, adaptors, and actin binding and regulating proteins. In <italic>Drosophila<italic> <italic>abl<italic> was specifically found to genetically interact with <italic>disabled<italic> (<italic>dab<italic>), an adaptor that also binds to Notch, a receptor that genetically interacts with <italic>abl<italic>. Dab is the link that transmits extracellular signals to the kinase signaling module. In this study we sought to dissect how the protein structure of Dab contributes to the mechanism of Abl function in the nervous system both <italic>in vivo<italic> and <italic>in vitro<italic>.
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  • In Copyright
Advisor
  • Crews, Stephen
  • Peifer, Mark
  • Giniger, Edward
  • Rogers, Stephen
Degree
  • Master of Science
Degree granting institution
  • University of North Carolina at Chapel Hill Graduate School
Graduation year
  • 2014
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  • Chapel Hill, NC
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