Group A p21-activated kinases in radial neuronal migration Public Deposited

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  • March 21, 2019
  • Halberstadt, Ari I.
    • Affiliation: School of Medicine, Department of Biochemistry and Biophysics
  • The p21-activated kinases (PAKs) are downstream effectors of signal transducers including Rac and Cdc42. PAKs are involved in cytoskeletal rearrangements during cell migration, mitosis, dendritic spine formation, and neurite outgrowth. While the general expression pattern of PAKs in the brain was known, possible effects of PAK kinase activity on early brain development had not been described. I studied the expression pattern of activated PAKs 1-3 by immunoblotting and immunofluorescence in embryonic mouse brains and the effect of disruption of PAK activity during development on radial migration and early neuronal remodeling at the cortical plate. Active PAKs were observed in progenitor cells, in which they were coexpressed with PAK1 phosphorylated at T212, and in the developing cortical plate. Disruption of PAK activity did not affect radial cell distribution in the neocortex or neurite number in early neurons in the cortical plate.
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  • Maness, Patricia
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  • University of North Carolina at Chapel Hill
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