Associations Between Biochemical Markers of Cartilage Metabolism and Gait Biomechanics in Healthy Participants Public Deposited
- Last Modified
- March 20, 2019
- Creator
-
Davis, Hope
- Affiliation: College of Arts and Sciences, Department of Exercise and Sport Science
- Abstract
- Introduction: Mechanical loading is associated with cartilage breakdown in people with knee osteoarthritis (KOA); it is unknown if this association exists in healthy young individuals. Purpose: Determine associations between biomarkers of collagen turnover (synthesis:breakdown) and peak vertical ground reaction force (vGRF) in healthy young individuals. Methods: Resting serum samples and walking gait kinetics were collected from 24 healthy, young individuals. Type II collagen synthesis (Collagen type II C- propeptide; CPII) and breakdown (Collagen type II cleavage product; C2C) were examined via enzyme-linked immunosorbent assays (ELISA). Gait kinetics were assessed during walking trials. Pearson product (r) moment correlations were used to determine associations between transformed (base-10 log scale) collagen turnover and peak vGRF. Results: 24 subjects (age=20±2 years, BMI=23.4±3.0) completed this study. There was a moderate association between CPII:C2C ratios and peak vGRF approaching significance (r= 0.363, p=0.081). Discussion: Higher loading in gait may increase collagen synthesis-to-degradation ratio in healthy young subjects.
- Date of publication
- May 2016
- Keyword
- DOI
- Resource type
- Rights statement
- In Copyright
- Advisor
- Hackney, Anthony
- Harkey, Matthew
- Pietrosimone, Brian
- Degree
- Master of Arts
- Degree granting institution
- University of North Carolina at Chapel Hill Graduate School
- Graduation year
- 2016
- Language
- Parents:
This work has no parents.
Items
Thumbnail | Title | Date Uploaded | Visibility | Actions |
---|---|---|---|---|
|
Davis_unc_0153M_16071.pdf | 2019-04-11 | Public |
|