The CRF-1 receptor antagonist, CP-154,526, attenuates stress-induced increases in ethanol consumption by BALB/cJ mice Public Deposited

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  • March 21, 2019
  • Lowery, Emily Geyer
    • Affiliation: College of Arts and Sciences, Department of Psychology and Neuroscience
  • Corticotropin-releasing factor (CRF) signaling modulates neurobiological responses to stress and ethanol, and may modulate increases in ethanol consumption following exposure to stressful events. The current experiment was conducted to characterize the role of CRF1 receptor (CRF1R) signaling in stress-induced ethanol consumption in BALB/cJ and C57BL/6N mice. Male BALB/cJ and C57BL/6N mice were given continuous access to 8% (v/v) ethanol and were exposed to 5 minutes of forced swim stress on each of 5 consecutive days preceded by an intraperitoneal injection of a 10 mg/kg dose of CP-154,526, a selective CRF1R antagonist. Exposure to forced swim stress significantly increased ethanol consumption by the BALB/cJ, but not of the C57BL/6N, mice. BALB/cJ mice pretreated with the CRF1R antagonist showed blunted stress-induced increases in ethanol intake. The present results provide evidence that CRF1R signaling modulates the delayed increase of ethanol consumption stemming from repeated exposure to a stressful event in BALB/cJ mice.
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  • Thiele, Todd
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  • University of North Carolina at Chapel Hill
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