Effects of functional disconnection of the basolateral mygdala and dorsal hippocampus following cocaine memory eactivation on subsequent drug context-induced cocaine-seeking behavior in rats Public Deposited

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  • March 20, 2019
Creator
  • Wells, Audrey M.
    • Affiliation: College of Arts and Sciences, Department of Psychology and Neuroscience
Abstract
  • Stimulus control over instrumental drug seeking relies on the reconsolidation of context-response-drug associations into long-term memory following retrieval-induced destabilization. According to previous studies, the basolateral amygdala (BLA) and dorsal hippocampus (DH) regulate cocaine-related memory reconsolidation; however, it is not known whether these brain regions interact or independently control this phenomenon. In the present study, using the contextual rodent extinction-reinstatement paradigm, we demonstrate that disruption of intrahemispheric (disconnection), but not interhemispheric (ipsilateral control), interactions between the BLA and DH following cocaine-related memory reactivation impaired subsequent drug context-induced cocaine-seeking behavior in rats. Furthermore, post-reactivation BLA/DH disconnection inhibited the development of a time-dependent increase, or incubation, of drug context-induced cocaine seeking following an extended delay, despite some recovery of cocaine-seeking behavior. Thus, the BLA and DH interact to regulate the reconsolidation of cocaine-related memories, thereby facilitating the ability of drug-paired contexts to trigger cocaine seeking and contributing to the incubation of cocaine seeking.
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  • "... in partial fulfillment of the requirements for the degree of Master of Arts in the Department of Psychology (Behavioral Neuroscience)."
Advisor
  • Fuchs, Rita
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  • Chapel Hill, NC
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  • Open access
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