Functional MRI Correlates of Schizophrenia Negative Symptoms during Auditory Oddball Task and Resting State

Public Deposited

Downloadable Content

Download PDF
Request Version for Screen Reader
Last Modified
  • March 19, 2019
Creator
  • Shaffer, Joseph
    • Affiliation: School of Medicine, UNC Neuroscience Center, Neuroscience Curriculum
Abstract
  • Background: The negative symptoms, including flattened affect, poverty of speech, avolition, and anhedonia, are important aspects of schizophrenia for which there are no effective treatments. Understanding the neural basis of these symptoms is an important step in developing therapies for treating these symptoms. Few studies have addressed this question, and most have treated negative symptoms as a singular category. We therefore utilize two large functional magnetic resonance imaging (fMRI) datasets to test the relationship between individual negative symptoms and functional activation and resting-state functional connectivity. Methods: The relationship between the severity of negative symptoms in schizophrenia patients and functional activation during an auditory oddball task (n = 89) and resting-state functional connectivity (n = 172) was assessed using correlation analysis and by contrasting patients with high severity symptoms with those with low severity symptoms in two datasets. Results: Activity and connectivity within limbic, striatal, default mode, and sensory processing networks were associated with negative symptoms and were differentially associated with individual negative symptom domains from the Scale for the Assessment of Negative Symptoms. Discussion: Our findings suggest that researchers should treat negative symptoms separately Furthermore, our results indicate a relationship between negative symptoms and a failure to suppress default-mode and sensory networks.
Date of publication
Keyword
Subject
DOI
Identifier
Resource type
Rights statement
  • In Copyright
Advisor
  • Grewen, Karen
  • Robinson, Donita
  • Dichter, Gabriel
  • Elston, Timothy
  • Belger, Aysenil
  • Perkins, Diana
  • Manis, Paul B.
Degree
  • Doctor of Philosophy
Degree granting institution
  • University of North Carolina at Chapel Hill Graduate School
Graduation year
  • 2015
Language
Publisher
Place of publication
  • Chapel Hill, NC
Access right
  • There are no restrictions to this item.
Date uploaded
  • June 23, 2015

Relations

Parents:

This work has no parents.

Items

Thumbnail Title Date Uploaded Visibility Actions
file details Shaffer_unc_0153D_15440.pdf 2019-04-10 Public Download