Pragmatic language in autism and fragile X syndrome: links with physiological arousal and anxiety Public Deposited

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  • March 22, 2019
Creator
  • Klusek, Jessica
    • Affiliation: School of Medicine, Department of Allied Health Sciences, Division of Speech and Hearing Sciences
Abstract
  • This dissertation is comprised of three manuscripts focused on delineating pragmatic language profiles in children with autism and fragile X syndrome, and on understanding the potential impact of physiological dysregulation on these profiles. The first manuscript presents a review of the existing literature on physiological arousal in autism and fragile X syndrome, with a focus on the relationship between arousal modulation and social competence. The second two manuscripts present original research: the first consists of a cross-population comparison of pragmatic language in autism and fragile X syndrome; the second extends upon this line of research by examining cardiac arousal as a mechanism that may play a role of social-communicative impairment in these disorders. These three manuscripts address the extent to which pragmatic language deficits overlap in autism and fragile X syndrome, and whether such deficits are linked with dysfunction of the autonomic nervous system. This work has implications for developing syndrome-specific interventions and ultimately may inform biological pathways that may be common to autism and fragile X syndrome.
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  • In Copyright
Advisor
  • Losh, Molly
Degree
  • Doctor of Philosophy
Graduation year
  • 2012
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