Acquisition of Heroin Conditioned Immunosuppression Requires IL-1 Signaling in the Dorsal Hippocampus Public Deposited
- Last Modified
- March 20, 2019
- Creator
-
Lebonville, Christina
- Affiliation: College of Arts and Sciences, Department of Psychology and Neuroscience
- Abstract
- Opioid users experience increased infection rates. While partially attributable to direct opiate-immune interactions, conditioned immune responses contribute as well. Neural circuitry governing opioid conditioned immune responses has been investigated, but mediating mechanisms are unknown. Previous studies showed that hippocampal IL-1 signaling is required for expression of heroin conditioned immunosuppression following learning. Current studies were designed to further characterize hippocampal IL-1’s role in this phenomenon by manipulating IL-1 during learning. Experiment 1 tested whether hippocampal IL-1 is required for the acquisition of heroin conditioned immunosuppression. Experiment 2 tested whether hippocampal IL-1 is required for unconditioned heroin immunosuppression. Blocking IL-1 signaling in the dorsal hippocampus with IL-1RA during each conditioning session, but not on interspersed non-conditioning days, attenuated the acquisition of heroin conditioned immunosuppression. IL-1RA treatment did not alter unconditioned immunosuppression to a single dose of heroin. Thus, IL-1 signaling may play a role in learning the association between heroin and context.
- Date of publication
- August 2016
- Keyword
- DOI
- Resource type
- Rights statement
- In Copyright
- Advisor
- Thiele, Todd
- Carelli, Regina
- Lysle, Donald
- Degree
- Master of Arts
- Degree granting institution
- University of North Carolina at Chapel Hill Graduate School
- Graduation year
- 2016
- Language
- Parents:
This work has no parents.
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