Acquisition of Heroin Conditioned Immunosuppression Requires IL-1 Signaling in the Dorsal Hippocampus Public Deposited

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  • March 20, 2019
Creator
  • Lebonville, Christina
    • Affiliation: College of Arts and Sciences, Department of Psychology and Neuroscience
Abstract
  • Opioid users experience increased infection rates. While partially attributable to direct opiate-immune interactions, conditioned immune responses contribute as well. Neural circuitry governing opioid conditioned immune responses has been investigated, but mediating mechanisms are unknown. Previous studies showed that hippocampal IL-1 signaling is required for expression of heroin conditioned immunosuppression following learning. Current studies were designed to further characterize hippocampal IL-1’s role in this phenomenon by manipulating IL-1 during learning. Experiment 1 tested whether hippocampal IL-1 is required for the acquisition of heroin conditioned immunosuppression. Experiment 2 tested whether hippocampal IL-1 is required for unconditioned heroin immunosuppression. Blocking IL-1 signaling in the dorsal hippocampus with IL-1RA during each conditioning session, but not on interspersed non-conditioning days, attenuated the acquisition of heroin conditioned immunosuppression. IL-1RA treatment did not alter unconditioned immunosuppression to a single dose of heroin. Thus, IL-1 signaling may play a role in learning the association between heroin and context.
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  • In Copyright
Advisor
  • Thiele, Todd
  • Carelli, Regina
  • Lysle, Donald
Degree
  • Master of Arts
Degree granting institution
  • University of North Carolina at Chapel Hill Graduate School
Graduation year
  • 2016
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