Improvements to Real Time Aerosol Analysis using Ambient Sampling/Ionization Mass Spectrometry

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  • March 20, 2019
Creator
  • Swanson, Kenneth
    • Affiliation: College of Arts and Sciences, Department of Chemistry
Abstract
  • Ambient ionization is a family of techniques that requires very few or no sample preparation steps and has become an important area of research in analytical applications using mass spectrometry. Extractive electrospray ionization (EESI) is an ambient ionization technique that allows real-time sampling of organic aerosols. Similar to electrospray ionization, the composition of the electrospray solvent used in extractive electrospray ionization can easily be altered to change the chemistry of ionization. A novel EESI source design is presented to improve the reproducibility of the interactions occurring in EESI. This design uses three concentric capillaries to deliver solvent, sample and nebulizing gas. Coaxial EESI was found to improve the inter-experiment variation by a factor of four and intra-run relative standard deviation by a factor of 2.4. Unlike most standard EESI designs, the device has the form factor of a standard electrospray (ESI) emitter and can be used without any further instrument modifications. A simple design for an open port sampling interface coupled to electrospray ionization (OPSI-ESI) is also presented as a novel approach for the analysis of aerosols. The design uses minimal modifications to a Bruker ESI emitter to create a continuous flow, self-aspirating open port sampling interface. Upon comparison with EESI, this device has similar sensitivity with increased reproducibility by nearly a factor of three.
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Rights statement
  • In Copyright
Advisor
  • Gagné, Michel
  • Surratt, Jason
  • Glish, Gary
  • Ehrmann, Brandie
  • Jorgenson, James
Degree
  • Doctor of Philosophy
Degree granting institution
  • University of North Carolina at Chapel Hill Graduate School
Graduation year
  • 2018
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