The role of Sry-Box (Sox) transcription factors in epithelial stem cell biology of the gastrointestinal tract Public Deposited

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Last Modified
  • March 22, 2019
Creator
  • Gracz, Adam David
    • Affiliation: School of Medicine, Department of Cell Biology and Physiology
Abstract
  • Stem cell biology, though a well-established concept in the scientific zeitgeist, is only beginning to emerge as an independent field of study. An understanding of basic stem cell biology and its translation into clinically applicable therapies holds the potential to direct a paradigm shift in modern medical practice. However, in order to realize this potential, the scientific community must first understand the genetic and molecular mechanisms by which cells acquire and maintain 'stemness', specifically, multipotency and the ability to self-renew. Studying the transcriptional machinery that controls these properties could lead to a greater understanding of stem cells as a component of physiology as a whole. Due to its critical importance to homeostasis, the gastrointestinal tract is an attractive system for the study of stem cell biology. Sox factors, a group of transcription factors that have previously been associated with embryonic and neural stem cells, are rapidly emerging as central to maintaining 'stemness' in the gastrointestinal tract as well. This work reviews the known role of Sox factors in the gastrointestinal epithelium and describes our novel findings regarding Sox9 as a marker of stem cells in the adult intestinal epithelium.
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  • In Copyright
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  • "... in partial fulfillment of the requirements for the degree of Master of Science in the Department of Cell and Molecular Physiology."
Advisor
  • Magness, Scott
  • Lund, Pauline Kay
Degree granting institution
  • University of North Carolina at Chapel Hill
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Place of publication
  • Chapel Hill, NC
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  • Open access
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