Localized juvenile spongiotic gingival hyperplasia in adults; investigation of possible viral etiology and comparison with pyogenic granuloma Public Deposited

Downloadable Content

Download PDF
Last Modified
  • March 22, 2019
  • Mora-Gonzalez, Danny
    • Affiliation: School of Dentistry, Oral Pathology Section, Oral and Maxillofacial Pathology Graduate Program
  • Localized Juvenile Spongiotic Gingival Hyperplasia (LJSGH) has been recognized in adults in our laboratory. This study reports histopathologic and clinical findings in a group of adults with lesions identical to those in LJSGH and offers evidence for change in nomenclature. This retrospective study reviewed cases histopathologically diagnosed as pyogenic granuloma of the gingiva in patients over age 21 to determine the incidence of LJSGH in the adult population. qRT-PCR for detection of possible viral etiology was done for Human papillomavirus, Human hespesvirus and Human polyomavirus. Of the cases that qualified for review, 19 within an age range 21-84 met the histopathologic criteria previously reported for LJSGH. Additionally, previously unreported presence of eosinophils and mast cells were observed. We report 19 cases of LJSGH in adults similar to the cases previously reported in pediatric population. Therefore, we propose a modification of the name to localized spongiotic gingival hyperplasia (LSGH) so that the lesion can be recognized and studied in both populations. DNA was extracted from formalin fixed, paraffin embedded, tissue sections and was examined for the detection of HPV, HHV and Polyomavirus by Real Time PCR. Our findings also suggest investigation of hypersensitivity as a possible etiologic factor.
Date of publication
Resource type
Rights statement
  • In Copyright
  • Padilla, Ricardo J.
  • Master of Science
Degree granting institution
  • University of North Carolina at Chapel Hill
Graduation year
  • 2014

This work has no parents.