Bone Morphogenetic Protein Binding Endothelial Regulator (BMPER) Regulates Vascular Inflammatory Responses in Endothelial Cells

Bone Morphogenetic Protein Binding Endothelial Regulator (BMPER) Regulates Vascular Inflammatory Responses in Endothelial Cells Public Deposited

Last Modified

Creator

Lockyer, Pamela
- Affiliation: School of Medicine, Department of Pathology and Laboratory Medicine

Abstract

ABSTRACT Pamela P. Lockyer: Bone Morphogenetic Protein Binding Endothelial Regulator (BMPER) Regulates Vascular Inflammatory Responses in Endothelial Cells (Under the direction of Xinchun Pi) Dysfunction of the vascular endothelium results in various cardiovascular, circulatory and blood diseases highlighting the importance of endothelial integrity. How BMPER mediates signaling events to regulate endothelial cell functions in response to vascular injury with the expectation that these functions can be regulated to affect these vascular responses in clinically relevant pathophysiological conditions was the goal for these studies. Aim 1-We crossed ApoE−/− and Bmper+/− and measured the development of atherosclerosis in mice fed a high-fat diet. BMPER haploinsufficiency in ApoE−/− mice led to a more severe phenotype. Aim 2-BMPER+/− were used for LPS challenge. LPS-induced pulmonary inflammation and injury was reduced in BMPER+/- mice. We conclude that BMPER is essential in the maintenance of normal vascular homeostasis during chronic inflammation and atherosclerosis. Furthermore, BMPER plays a pivotal role in pulmonary inflammatory response, to provides new therapeutic options against septic shock, and broadens our understanding of BMPER’s role in vascular homeostasis.

Date of publication

Keyword

Resource type

Rights statement

Advisor

Degree

Degree granting institution

Graduation year

Language

Thumbnail	Title	Date Uploaded	Visibility	Actions
	Lockyer_unc_0153M_17338.pdf	2019-04-11	Public	Download