Topographic characteristics of EEG responses to auditory tasks- comparisons between healthy individuals and participants with schizophrenia Public Deposited

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  • March 19, 2019
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  • Boyle, Michael
    • Affiliation: School of Medicine, UNC/NCSU Joint Department of Biomedical Engineering
Abstract
  • Electroencephalographic measures of auditory sensory processing deficits in schizophrenia have become well established1-3. While deviations from typical EEG dynamics are well characterized in the time domain at a few recording locations, differences in the spatial architecture of these responses between healthy and patient populations remains understudied. We acquired 128 channel hdEEG from 12 healthy humans while they completed auditory oddball and auditory click train tasks. We calculated wavelet transformations and extracted measures of evoked and induced activity to compare the topography of these EEG responses between stimulus types within the two auditory tasks. We found distinct topographies for different click train frequencies but not for the standard and deviant trials in the oddball task. As a preliminary analysis of a clinical trial, we subjectively compared the group mean healthy topographies to three individuals with schizophrenia. We found deficits in induced 10Hz power to 10Hz click trains compared to healthy individuals.
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  • In Copyright
Advisor
  • Gomez, Shawn
  • Grose, John
  • Frohlich, Flavio
Degree
  • Master of Science
Degree granting institution
  • University of North Carolina at Chapel Hill Graduate School
Graduation year
  • 2015
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  • Chapel Hill, NC
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