Total synthesis of (-)-Pironetin and Studies Directed Toward the Total Synthesis of Iriomoteolide 1a Public Deposited

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  • March 22, 2019
Creator
  • Dechert, Anne-Marie Roe
    • Affiliation: College of Arts and Sciences, Department of Chemistry
Abstract
  • Polyketides are secondary metabolites with diverse structural scaffolds. The research summarized herein describes the biomimetic total synthesis of the polyketide (-)-pironetin utilizing iterative aldol additions of thiazolidinethiones to create five of the six total stereocenters of (-)-pironetin. This technology has also been applied to a convergent synthesis of the core of the polyketide iriomoteolide 1a.
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  • In Copyright
Advisor
  • Crimmins, Michael T.
Degree
  • Doctor of Philosophy
Graduation year
  • 2011
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