The effect of intracanal corticosteroids on healing of replanted dog teeth after extended dry times Public Deposited

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  • March 22, 2019
  • Kirakozova, Anna Ole
    • Affiliation: School of Dentistry, Department of Endodontics
  • Corticosteroids may inhibit unfavorable periodontal healing of replanted avulsed teeth. Aims: 1) investigate the effect of potent intracanal corticosteroids on periodontal healing; 2) evaluate systemic absorption of intracanal corticosteroids. Methods: 67 dog premolar roots were extracted. Groups 1-3 were filled with gutta-percha and replanted immediately, after 40- and 60 min, respectively. Groups 4 and 5 were filled with 0.05% clobetasol. Groups 6 and 7 were filled with 0.05 % fluocinonide. Groups 4 and 6 were replanted after 40 min; groups 5 and 7 after 60 minutes. After 4 months, roots were evaluated histologically for type of periodontal healing. Results: Groups treated with clobetasol and fluocinonide healed more favorably than groups filled with gutta-percha and were different from each other at 60 min. No change in the systemic corticosteroid blood concentration was observed with any of the intracanal corticosteroids. Conclusion: Corticosteroids were efficacious as intracanal medicaments for promoting favorable periodontal healing.
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  • Trope, Martin
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  • University of North Carolina at Chapel Hill
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