Chronic Early Childhood Exposure to Inorganic Arsenic is Associated with a TNF-mediated Proteomic Signaling Response Public Deposited

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  • March 21, 2019
Creator
  • Smeester, Lisa
    • Affiliation: Gillings School of Global Public Health, Department of Environmental Sciences and Engineering
Abstract
  • Exposure to inorganic arsenic (iAs) in drinking water remains a global issue of concern and is associated with a range of health outcomes, including immune dysfunction. Young children have been identified as a particularly sensitive population, yet mechanisms of adverse health outcomes are understudied. Here we set out to examine the effects of iAs exposure on circulating serum proteins in adolescents. To identify proteins as potential indicators of disease, levels of total urinary arsenic (U-tAs) and its methylated metabolites were determined and serum proteins assessed for differences in expression. The results indicate an enrichment of TNF-regulated immune and inflammatory response proteins that display decreased expression levels in relation to increasing U-tAs. Notably, when analyzed in the context of the arsenical proportions, there was minimal overlap between the protein lists, with the most robust response observed in relation to %MMAs. These data represent the first assessment of protein expression in serum in adolescents exposed to inorganic arsenic.
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  • In Copyright
Advisor
  • Fry, Rebecca
  • Stewart, Jill
  • Nylander-French, Leena A.
Degree
  • Master of Science
Degree granting institution
  • University of North Carolina at Chapel Hill Graduate School
Graduation year
  • 2016
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