Neuromodulation of intrinsic and synaptic plasticity in auditory cortex Public Deposited

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Last Modified
  • March 20, 2019
Creator
  • Rao, Deepti
    • Affiliation: School of Medicine, Department of Cell and Molecular Physiology
Abstract
  • The study of auditory system development and plasticity is important. Large populations of people suffer from hearing loss throughout their lifetime. To optimize treatment for children with hearing loss, it is crucial to understand how early hearing loss affects the development and processing of the central auditory system. Equally important is the understanding of how changes in neural activity in the auditory pathways can have an effect on its function. In this thesis, I studied 1) how hearing loss affects auditory cortical activity and 2) the mechanisms that could underlie learning and memory of sound information. In the first study, I found that hearing loss enhances auditory cortical activity and alters the manner in which the auditory cortex responds to the neuromodulator serotonin. In the second study, I found that the auditory cortex follows unique cellular learning and memory rules and these rules are altered by the neuromodulator acetylcholine.
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  • In Copyright
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  • "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy at the Department of Cell and Molecular Physiology in the School of Medicine"
Advisor
  • Manis, Paul B.
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Place of publication
  • Chapel Hill, NC
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  • Open access
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