THE EFFECT OF ACUTE EXERCISE ON MUCOSAL ASSOCIATED INVARIANT T-CELL ACTIVITY IN MODERATELY TRAINED YOUNG MALES Public Deposited

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  • March 20, 2019
Creator
  • Danson, Eli
    • Affiliation: College of Arts and Sciences, Department of Exercise and Sport Science
Abstract
  • Purpose: To determine circulating mucosal associated invariant T (MAIT) cell number, frequency and activation and chemokine receptor expression in response to submaximal exercise. Methods: 20 young men performed a VO2max test and then exercised for 40 minutes at 86% of ventilatory threshold (VT). Immune cells were isolated from blood samples obtained at rest and after 0h and 1h of recovery. Results: MAIT cell counts significantly increased by 92% (p=0.003) at 0h before returning to baseline at 1h. MAIT cells were preferentially mobilized, rising from 2.9% of T-cells at baseline to 4.5% at 0h and 4.6% at 1h (p=0.002). MAIT cell chemokine and activation marker expression was not affected by exercise. Conclusion: MAIT cells follow a biphasic response and are preferentially mobilized within the T cell subsets. MAIT cell numbers expressing activation and homing markers following exercise are higher but are driven by the exercise-stimulated lymphocytosis, rather than intrinsic cellular changes.
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  • In Copyright
Advisor
  • Sakkal, Samy
  • Hanson, Erik
  • Battaglini, Claudio L.
Degree
  • Master of Arts
Degree granting institution
  • University of North Carolina at Chapel Hill Graduate School
Graduation year
  • 2017
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