Obesity induces metabolic alterations of T lymphocytes in influenza-vaccinated adults Public Deposited

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  • March 19, 2019
Creator
  • Green, William
    • Affiliation: Gillings School of Global Public Health, Department of Nutrition
Abstract
  • Obesity increases the risk for infection due to impairments in T cell activation and function. Although the metabolic profiles of T cells dictate their function, what remains unknown is if obesity alters T cell metabolism, thereby impairing function. This study examined the metabolic profiles of T cells from healthy weight and obese white women. We demonstrated that obesity alters the metabolic profile of quiescent and activated peripheral blood mononuclear cells, and isolated CD4 and CD8 T cells. T cells from obese non-diabetic subjects exhibited higher rates of aerobic glycolysis and mitochondrial respiration compared to obese metformin-treated diabetic subjects. This ability of metformin to lower T cell metabolism in obese diabetics to healthy weight levels, despite elevated serum glucose, suggests that metformin’s mechanism of action directly impacts T cells. These results suggest that perturbations in T cell metabolism are the mechanism for impairment of T cell function in obese adults.
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  • In Copyright
Advisor
  • Hursting, Stephen
  • Coleman, Rosalind
  • Beck, Melinda A.
Degree
  • Master of Science
Degree granting institution
  • University of North Carolina at Chapel Hill Graduate School
Graduation year
  • 2017
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