Affiliation: College of Arts and Sciences, Department of Psychology and Neuroscience
Support exists for inhibitory control and working memory deficits among cocaine users. Existing literature suggests that working memory is central in successful inhibitory control, and that working memory processes may be best captured by examining network connectivity. This study examined whether working memory network connectivity mediates the relationship between group (cocaine users versus controls) and working memory performance, and group and inhibitory control performance. Participants completed working memory and inhibitory control tasks during functional magnetic resonance imaging. Cocaine users demonstrated poorer inhibitory control performance and reduced activation during the working memory task compared to controls. Working memory network connectivity did not account for group differences in working memory or inhibitory control performance. Specific connectivity between the right insula and inferior frontal gyrus and the right precuneus and inferior parietal lobule were significantly related to working memory and inhibitory performance, respectively, suggesting the role of attention and default mode network regulation.