Association Between Quadriceps Strength and Tibiofemoral Cartilage Proteoglycan Density at 6 Months Following Anterior Cruciate Ligament Reconstruction Public Deposited

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Last Modified
  • March 21, 2019
Creator
  • Hunt, Christian
    • Affiliation: College of Arts and Sciences, Department of Exercise and Sport Science
Abstract
  • Anterior Cruciate ligament (ACL) injury is common in the active population. ACL Reconstruction (ACLR) is used to restore stability and allow for return to activity post-ACL injury. A common impairment following ACLR is decreased quadriceps strength in the injured limb, which has been linked to the development of Tibiofemoral Osteoarthritis (OA). Compositional magnetic resonance imaging (MRI) has shown the ability to identify early cartilage changes prior to cartilage structural damage. This preliminary investigation evaluated the association between isometric quadriceps strength and T1rho compositional MRI in weight-bearing regions of tibiofemoral cartilage in 24 subjects at 6 months post-ACLR. We found evidence of compositional changes, measured via T1rho relaxation time, with little change to cartilage volume. There was also a statistically significant association between quadriceps strength and T1rho relaxation times for the three regions of the medial femoral condyle, calling for additional research into the interaction of quadriceps and cartilage composition.
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Rights statement
  • In Copyright
Advisor
  • Pietrosimone, Brian
  • Harkey, Matthew
  • Blackburn, J. Troy
Degree
  • Master of Arts
Degree granting institution
  • University of North Carolina at Chapel Hill Graduate School
Graduation year
  • 2017
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