Sensory experience-dependent synaptic modifications in the visual cortex Public Deposited

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Last Modified
  • March 20, 2019
Creator
  • Yashiro, Koji
    • Affiliation: School of Medicine, Department of Cell and Molecular Physiology
Abstract
  • During early postnatal development, the brain receives tremendous input from developing sensory organs. These sensory inputs shape neuronal networks in the cortex so as to adapt the neuronal circuits to the animal's living environment. Thus, synaptic connections in the cortex mature in a sensory experience-dependent manner. In this thesis, I studied 1) an endogenous mechanism that is crucial for regulating normal, experience-dependent synaptic modification in adult rodents, and 2) how dysregulation of experience-dependent plasticity contributes to a severe mental retardation, Angelman syndrome.
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Rights statement
  • In Copyright
Advisor
  • Sealock, Robert
  • Ehlers, Michael
  • Manis, Paul B.
  • Philpot, Benjamin
  • Dudek, Serena
Degree
  • Doctor of Philosophy
Degree granting institution
  • University of North Carolina at Chapel Hill Graduate School
Graduation year
  • 2008
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  • This item is restricted from public view for 2 years after publication.
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