Interactions between intracerebral human immunodeficiency virus-1 glycoprotein 120 and systemic heroin on expression of messenger ribonucleic acid (mRNA) of inducible nitric oxide synthase, interleukin-1β, tumor necrosis factor-α, and cyclooxygenase-2 in hippocampus and cortex brain tissue of the Lewis rat Public Deposited

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  • March 21, 2019
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  • Wagner, Alison F.
    • Affiliation: College of Arts and Sciences, Department of Psychology and Neuroscience
Abstract
  • Neurological complications caused by interactions of the immune system and the nervous system commonly occur in human immunodeficiency virus patients (HIV). Intravenous drug users, including heroin users, have increased rates of HIV-induced pathology in the brain. Glycoprotein 120 (gp120), a coat protein of HIV, has been implicated as a possible causative factor. These experiments examined an in vivo model of HIV infection in the brain by injecting gp120 into the lateral ventricles of Lewis rats with and without systemic heroin administration. The effects of gp120 and heroin were measured in expression of messenger RNA (mRNA) for the important proinflammatory mediators inducible nitric oxide synthase, interleukin-1β, tumor necrosis factor-α, and cyclooxygenase-2 in hippocampus and cortex tissue. The results of these experiments indicate that heroin may uniquely alter the acute effects of gp120 in the rat brain on mRNA, allowing increased expression of interleukin-1β and inducible nitric oxide mRNA.
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  • In Copyright
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  • Lysle, Donald
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  • Open access