Understanding paclitaxel/pluronic F127 nanocrystals prepared by the stabilization of nanocrystal (SNC) method Public Deposited

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  • March 21, 2019
Creator
  • Deng, Jiexin
    • Affiliation: Eshelman School of Pharmacy, Division of Pharmacoengineering and Molecular Pharmaceutics
Abstract
  • The objectives of this study were to understand the structure and stability of paclitaxel nanocrystals, as well as the biodistribution of nanocrystals after intravenous injection in mice. The nanocrystal size increased after 2 h 37 oC incubation due to thermal induced aggregation. The addition of more F127 surfactant further destabilized nanocrystals and led to a larger size increase concurrent with micelle formation. PTX/F127 nanocrystals (1/5 w/w) had little size increase upon dilution, indicating tight monomer surfactant absorption. Nanocrystals of more F127 surfactant (1/20, 1/30 w/w) increased much in size upon dilution, suggesting low-affinity surfactant absorption with micelle formation in solution. The re-nanonization after 37 oC incubation effectively inhibited crystal growth after 37 oC incubation again by disturbing the preferred crystal growth pattern of PTX. The biodistribution of nanocrystals revealed that the majority of nanocrystals were quickly taken up by reticuloendothelial system and went to the liver 1 h post injection.
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  • In Copyright
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  • "... in partial fulfillment of the requirements for the degree of Master of Science in the Division of Molecular Pharmaceutics at Eshelman School of Pharmacy."
Advisor
  • Smith, Philip
Degree granting institution
  • University of North Carolina at Chapel Hill
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Place of publication
  • Chapel Hill, NC
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  • Open access
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