A Study of Prostate Cancer by Using Single-Voxel and Hadamard Multi-Voxel 2D Localized COSY and JPRESS MR Spectroscopy Techniques Public Deposited

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  • March 19, 2019
  • Liu, Hui
    • Affiliation: School of Medicine, UNC/NCSU Joint Department of Biomedical Engineering
  • Prostate cancer is the most common cancer among men in the western countries. It grows indolently and can take more than 10 years to turn deadly. Currently no imaging methods can provide both high sensitivity and specificity for prostate cancer detection and characterization. 1H Magnetic Resonance Spectroscopy (MRS) is a non-invasive technique, which can provide biochemical information of the prostate gland. (Choline + Creatine)/ Citrate ratio is widely used as a criterion for the diagnosis of prostate cancer. The specificity of multi-voxel 1D* 1H MRS is still limited due to the severe overlap of 1D* 1H MRS spectrum and voxel bleeding artifacts. Two-dimensional 1H MRS, which spreads the metabolite resonance peaks on a two-spectral dimensional surface, can help to differentiate most of the overlapping resonance peaks compared to conventional 1D* MRS spectrum. In the present study, a Hadamard multi-voxel 2D* localized COrrelated SpectroscopY (COSY) MRS technique was developed and implemented on a whole-body 4T MR system. The combination of localized 2D* 1H MR correlation spectroscopy and Hadamard encoding enables the simultaneous acquisition of multiple volumes of interest with the benefits of improved spectral resolution, increased SNR without an increase in the experimental duration, and with limited voxel bleeding compared to 1D* CSI acquisition. Most of the metabolites were measured without contamination of other resonances. The developed technique solves the severe resonances overlap problem in 1D* 1H MR spectra and offers multi-regional analysis of MRS due to the multi-focal and heterogeneous nature of prostate adeno-carcinoma, which can be easily overlooked by a single-voxel based MR spectroscopy method. By using this technique, more metabolites can be identified and additional information about the metabolites can be gained from the extended 2D* MRS spectra. This offers an opportunity to accurately follow up the metabolism in vivo. New biomarker of prostate cancer -polyamine spermine resonances are very well-resolved in 2D* L-COSY spectra and can be traced longitudinally by its cross-peaks for chemoprevention research of prostate cancer. 2D* Localized J-resolved Pointed RESolved Spectroscopy (JPRESS) MRS technique was also implemented to compare it with the 2D* L-COSY technique. The advantages and disadvantages of both techniques are thoroughly investigated.
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  • Nalcioglu, O.
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