Investigation of the Methylation Status of FGF2 Gene in Periodontal Tissues as Determinants of Healing Response After Implant Surgery

Investigation of the Methylation Status of FGF2 Gene in Periodontal Tissues as Determinants of Healing Response After Implant Surgery Public Deposited

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Wu, Ping Seung Alice
- Affiliation: School of Dentistry, Department of Periodontology

Abstract

Periodontal wound healing is a complex process involving a series of interactions of growth factors, including FGF2. Previous studies suggested FGF2 gene may be down-regulated in diseased periodontal tissues. Aberrant gene expression in smokers and diabetics has also been reported. The aims of this study were to determine the association of FGF2 methylation level with wound healing after implant surgery and the association of smoking and diabetes with FGF2 methylation. Recruited subjects were distributed into control, smoking and diabetic groups. During the implant surgery, gingival tissue biopsies were collected at the surgical site. GCF samples, implant stability and wound healing index were collected / measured at 2, 4 and/or 6 weeks after surgery. This study demonstrated that hyper-methylation and down-regulation of mRNA expression of FGF2 were associated with smoking and diabetes, and differential methylation of FGF2 was also associated with implant stability during wound healing.

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