Feasibility Study of a Home-based Exercise Intervention Program for Patients with Metastatic Castration-Resistant Prostate Cancer Receiving Androgen-Deprivation Therapy Public Deposited

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  • March 21, 2019
Creator
  • Carver, Jackson
    • Affiliation: College of Arts and Sciences, Department of Exercise and Sport Science
Abstract
  • Abstract Jackson Luke Carver: Feasibility Study of a Home-based Exercise Intervention Program for Patients with Metastatic Castration-Resistant Prostate Cancer Receiving Androgen-Deprivation Therapy Under supervision of Dr. Erik Hanson Purpose: To assess the feasibility of home-based exercise in men with metastatic castration-resistant prostate cancer (mCRPC) receiving androgen deprivation therapy (ADT). Methods: Men with mCRPC undergoing ADT completed body composition, muscular function, physical function, and cardiorespiratory fitness assessments before and after a 12-week home-based exercise intervention. Adherence to the intervention was monitored using a Garmin vivosmart HR device. Changes in fitness parameters were assessed using paired-samples t-tests. Results: Of the 10 men who completed baseline testing, 70% completed post-testing. Each of these men adhered to greater than 75% of planned walking and resistance training sessions. Significant improvements were found in lower body strength (p=0.023) and cardiorespiratory fitness (p=0.013). Conclusion: A home-based exercise intervention appears to be feasible in men with mCRPC undergoing ADT.
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  • In Copyright
Advisor
  • Hackney, Anthony
  • Hanson, Erik
  • Battaglini, Claudio
Degree
  • Master of Arts
Degree granting institution
  • University of North Carolina at Chapel Hill Graduate School
Graduation year
  • 2018
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