Dendritic Cell Regulation of B Cells Public Deposited

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Last Modified
  • March 20, 2019
Creator
  • Carnathan, Diane Gail
    • Affiliation: Gillings School of Global Public Health, School of Medicine, Department of Microbiology and Immunology
Abstract
  • The innate and adaptive immune responses protect from autoimmunity during infection through B cell tolerance mechanisms. We previously showed that during innate immune responses dendritic cells (DCs) and macrophages (MΦs) repress autoantibody secretion in part through their secretion of soluble factors (IL-6 and CD40L). Herein I describe that DCs from lupus-prone mice are deficient in repressing autoreactive B cell coincident with their inability to secrete IL-6. This defect results from defective Toll-Like Receptor signal transduction. We further describe that DCs repress innate and adaptive immune responses independent of DC/MΦ-derived soluble factors. We show that DCs display endogenous nuclear self antigens and affect B cells responses as evidenced by upregulation of CD69 expression, induction of IκB phosphorylation and destabilization of the BCR. Despite evidence of stimulation, DCs inhibit BCR-derived signals and LPS-induced Ig secretion in autoreactive and naïve B cells suggesting that DCs regulate B cell responses independent of self-antigen.
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  • In Copyright
Advisor
  • Vilen, Barbara J.
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  • Open access
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Dendritic cell regulation of B cells 2019-04-10 Public