METABOLIC CHARACTERIZATION OF MICE LACKING CARBONIC ANHYDRASE III Public Deposited

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Last Modified
  • March 21, 2019
Creator
  • Renner, Sarah
    • Affiliation: School of Medicine, Curriculum in Genetics and Molecular Biology
Abstract
  • Carbonic anhydrases (CAs) are a family of enzymes that catalyze the reversible condensation of water and carbon dioxide to bicarbonate and a proton. While CA III shares homology with α-CA family members, it has only 0.16% of the catalytic activity compared to other CAs. Despite the abundance of CA III in many metabolic tissues that are able to store lipids, a physiological role for CA III is currently unclear. Since CA III is nutritionally regulated, we utilized mouse genetics to evaluate the possible role of CA III in metabolism. Even though we found no obvious differences in metabolic phenotypes of mice deficient in CA III, we eliminated a potential function: CA III is not required for de novo lipogenesis. The role of CA III continues to be elusive, however it remains to be seen what phenotypes CA III deficient mice have under abnormal laboratory conditions.
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  • In Copyright
Advisor
  • Brenman, Jay
  • Pomp, Daniel
  • Coleman, Rosalind
  • Mohlke, Karen
  • Bultman, Scott
Degree
  • Doctor of Philosophy
Degree granting institution
  • University of North Carolina at Chapel Hill
Graduation year
  • 2017
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