Progress towards the total synthesis of pyrancin Public Deposited

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Last Modified
  • March 21, 2019
Creator
  • Jacobs, Danielle L.
    • Affiliation: College of Arts and Sciences, Department of Chemistry
Abstract
  • Progress towards the total synthesis of pyrancin, a structurally-unique member of the annonaceous acetogenin family of natural products, is reported. Methodology includes an asymmetric glycolate aldol reaction and an asymmetric glycolate alkylation to install key stereocenters in the natural product. Several strategies towards uniting the pyranicin skeletal backbone are evaluated.
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  • In Copyright
Advisor
  • Crimmins, Michael T.
Degree granting institution
  • University of North Carolina at Chapel Hill
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  • Open access
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