Bone Blood Perfusion Increases with Diet-Induced Obesity, Associated with Trabecular Deterioration in Mice [abstract]
Public Deposited- Creator
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Hanne, Nicholas J.
- School of Medicine, Lampe Joint Department of Biomedical Engineering
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Steward, Andrew J.
- School of Medicine, Lampe Joint Department of Biomedical Engineering
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Easter, Elizabeth
- Other Affiliation: Materials Science and Engineering Department, North Carolina State University, Raleigh, NC
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Cole, Jacqueline
- School of Medicine, Lampe Joint Department of Biomedical Engineering
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Hanne, Nicholas J.
- Abstract
- Introduction: In addition to cardiovascular problems (e.g., peripheral artery disease, ischemic stroke), individuals with obesity and metabolic disease experience higher bone fracture rates, despite having greater bone mass than healthy individuals. We hypothesized that vascular changes with obesity are systemic and, because vascular function is critical for bone development and repair, changes to vasculature within bone contribute to decreases in bone health with obesity. Further, exercise stimulates vascular growth and performance and may be an effective intervention to ameliorate chronic changes in bone vasculature [1]. We aim to correlate changes in trabecular architecture with changes in bone vasculature due to obesity and exercise.
- Date of publication
- October 7, 2016
- Keyword
- DOI
- Resource type
- Conference Proceeding
- Rights statement
- In Copyright
- Journal title
- Proceedings of the Biomedical Engineering Society Annual Meeting
- Version
- Preprint
- Language
- English
- Date uploaded
- February 8, 2017
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- Parents:
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