Exercise: A Possible Mediator in the Enhanced Antibody Response to Influenza Vaccination in Healthy Weight and Overweight Individuals
Public Deposited- Last Modified
- February 26, 2019
- Creator
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Riley, Marissa
- Affiliation: Gillings School of Global Public Health, Department of Nutrition
- Abstract
- In recent years, the obesity epidemic has continued to grow and has emerged as a huge public health issue over the last decade. Obesity has been found to be associated with a multitude of health problems including cardiovascular disease, metabolic syndrome, arthritis and overall morbidity. Additionally, obesity has been linked to a decreased antibody immune response to influenza vaccination. Exercise is commonly understood to have health benefit, both in mental and physical health, but the association between exercise and immune response is an area of limited research. The present study aimed to investigate whether exercise in both healthy weight and overweight individuals would enhance the antibody immune response following influenza vaccination. Pre- and post- vaccination serum samples from the 2013-2014 study year were used to determine vaccine antibody titer response using haemagglutination inhibition assays. Exercise data for the subjects was collected from a self-reported questionnaire administered upon pre-vaccination blood draw. There were no significant differences between pre- and post-vaccination antibody titers between non-exercisers and exercisers nor was there one between the four body weight-exercise subgroups. As such there was also no significant difference between antibody titer fold change between subgroups. Although the data was restricted by limited sample size and possible subgroup misclassifications and no significant differences were found, there were trends that may suggest that exercise plays a role in mediating the antibody immune response in healthy weight and overweight individuals.
- Date of publication
- spring 2016
- Keyword
- DOI
- Resource type
- Rights statement
- In Copyright
- Note
- Funding: None
- Advisor
- Beck, Melinda A.
- Degree
- Bachelor of Science in Public Health
- Honors level
- Highest Honors
- Degree granting institution
- University of North Carolina at Chapel Hill
- Extent
- 24
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