A Novel Method for Reducing Transmission of Mycobacterium Tuberculosis in Malaria-Endemic Areas: A Literature Review Public Deposited

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Last Modified
  • February 27, 2019
Creator
  • Broadhurst, Richard
    • Affiliation: Gillings School of Global Public Health, Department of Environmental Sciences and Engineering
Abstract
  • In order to assess the possibility of adding an antimicrobial agent to insecticide treated nets already used for malaria prevention to expand their purpose and reduce in-home transmission of Mycobacterium tuberculosis, an extensive literature review was conducted. The review focused on the methodology of assessment of filtration efficacy of masks, antimicrobial effects of compounds that are commonly used in insecticide treated nets, generic biocidal compounds, and the use of electrostatic effects to attract Mycobacterium tuberculosis. Our hypothesisis that if a significant amount of the aerosolized bacteria can be arrested by the net, while still allowing for comfortable sleeping conditions and protection against malaria transmission, then tuberculosis incidence rates in malaria-endemic areas could be decreased. The findings from 16 relevant studies suggest that there is no universal standard method for testing filters and masks using bioaerosol challenge techniques. Permethrin, the most widely used insecticide for insecticide treated nets, has no known antimicrobial effects. The compounds with the highest potential for biocidal effects are the AM 500 surface agent and cupron-based compounds. Given that Mycobacterium tuberculosis has an overall negative charge, positively charged compounds, such as quaternary amines, have a potential to arrest the bacteria. The systematic review of the literature will be used as a framework to move into the laboratory testing stage in order to determine the specific advantages and disadvantages of different approaches to develop the experimental net. We plan to partner with North Carolina State University, the Centers for Disease Control and Prevention, and Badir Dar University in Ethiopia in order to complete the final project. Our research is one of three separate efforts to create sustainable innovations in global health in order to advance the field and increase public health education capacity at Badir Dar University.
Date of publication
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Rights statement
  • In Copyright
Advisor
  • Van Rie, Annelies
  • Ball, Louise
Degree
  • Bachelor of Science in Public Health
Academic concentration
  • Environmental Health Sciences
Degree granting institution
  • University of North Carolina at Chapel Hill
Graduation year
  • 2012
Language
Deposit record
  • e00f1df6-6c31-41ba-867b-150d86a8c8cb
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