Multi-pollutant mixtures and their cardiac health effects in mice Public Deposited

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Last Modified
  • February 27, 2019
Creator
  • McIntosh-Kastrinsky, Rachel
    • Affiliation: Gillings School of Global Public Health, Department of Environmental Sciences and Engineering
Abstract
  • A growing body of evidence from epidemiological and toxicological studies indicates a strong link between air pollution and cardiovascular morbidity and mortality. Many studies have focused on the role of single pollutants, but this report along with others indicates the importance of ambient air pollutant mixtures. This report utilizes two different air pollution mixtures to underline the importance of moving from a single-pollutant approach to a multi-pollutant approach: (1) photochemically-altered volatile organic compounds (VOCs), nitric oxide and nitrogen dioxide (NOx) and ozone (O3) and (2) concentrated ambient particles [CAPs, fine (PM[2.5]) and ultrafine (UFP)] and O3. In both studies the Langendorff cardiac perfusion model was used to access cardiac function. In these studies, mice demonstrated decreased cardiac function after multi-pollutant exposure, as indicated by decreased ventricular pressure and contractility. These two studies together help demonstrate the complexity of gaseous and particulate multi-pollutants and their adverse cardiovascular health effects.
Date of publication
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Rights statement
  • In Copyright
Advisor
  • Diaz-Sanchez, David
  • Sexton, Kenneth
  • Jaspers, Ilona
Degree
  • Master of Science in Public Health
Academic concentration
  • Environmental Health Sciences
Degree granting institution
  • University of North Carolina at Chapel Hill
Graduation year
  • 2013
Language
Deposit record
  • 5edc2a5d-0dd3-4d26-87fc-ca03080ac860
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