Evaluation of an Inhalation Device to be Used in Cystic Fibrosis Research
Public Deposited- Last Modified
- February 28, 2019
- Creator
-
Thomas, Catherine A.
- Affiliation: Gillings School of Global Public Health, Department of Environmental Sciences and Engineering
- Abstract
- Powder aerosols are being considered as treatment for patients with Cystyic Fibrosis because powders can deliver amiloride hydrochloride directly to airway surfaces more quickly and easily than is possible when the drug is administered in solution. The goals of this research were: 1) to increase the fraction of respirable amiloride hydrochloride mass generated, 2) to remove larger, non-respirable particles from the aerosol before inhalation, and 3) to assess the effectiveness of these aerosol generation techniques for delivering amiloride to the lower airway surfaces. Three independent variables were tested, each at three levels: 1) size range of lactose powder flow-aid used to help disperse the amiloride aggregates 2) ratio of amiloride to lactose in the capsule, and 3) total mass of amiloride and lactose in the capsule. For the particle size of interest, 0.7 to 3.3 micrometers, all three independent variables had a significant effect on the fraction of respirable amiloride hydrochloride mass generated. For size range of lactose flow-aid used to disperse amiloride aggregates, the trend indicated that smaller lactose particles, <38 um, were most effective. For ratio of amiloride to lactose, a 1:2 ratio of lactose flow-aid to amiloride drug was most effective. For total mass of amiloride and lactose in the capsule, the least mass, 30 mg, was most effective in dispersing amiloride aggregates.
- Date of publication
- May 1987
- DOI
- Resource type
- Rights statement
- In Copyright
- Advisor
- Flynn, Michael
- Leith, David
- Knowles, Michael
- Degree
- Master of Science in Public Health
- Academic concentration
- Industrial Hygiene
- Degree granting institution
- University of North Carolina at Chapel Hill
- Graduation year
- 1987
- Language
- Deposit record
- 4229e0fb-b010-4ede-aa50-9d4a2f0726fb
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