Application of a Generalized State-Vector Model for Radiation-Induced Dellular Transformation to Multiple In Vivo Exposures
Public Deposited- Last Modified
- February 28, 2019
- Creator
-
Martin, Donna G.
- Affiliation: Gillings School of Global Public Health, Department of Environmental Sciences and Engineering
- Abstract
- A generalized state vector model for radiation induced cellular transformation is adapted for use in multiple in vivo chemical and radiation exposures. The model was designed to describe the process of radiation carcinogenesis and thus provides for initiation, promotion, and progression as well as cell killing and repair. The model has been modified to describe the combined effects of chemical and radiation induced cell transformation. Benzo(a)pyrene and polonium-210 markers for environmental tobacco smoke and radon, respectively, were chosen for this study because it is very possible that they will be present together in a variety of indoor environments. The data chosen to test the model come from an experiment by McGandy et al. (1974) in which Syrian golden hamsters were exposed both simultaneously and sequentially to polonium-210 and benzo(a)pyrene. The results demonstrate that the proposed model can correctly predict that BaP synergism occurs more strongly with high doses of alpha radiation. In addition, the model correctly predicts the increase in tumors found at exposure to low doses of alpha radiation followed by exposure to BaP.
- Date of publication
- August 1990
- DOI
- Resource type
- Rights statement
- In Copyright
- Advisor
- Turner, Alvis G.
- Ball, Louise
- Crawford-Brown, Douglas J.
- Degree
- Master of Science in Public Health
- Academic concentration
- Environmental Management and Policy
- Degree granting institution
- University of North Carolina at Chapel Hill
- Graduation year
- 1990
- Language
- Deposit record
- ad7e9272-7c4f-43e0-afeb-7a5f2526ad76
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