OPPERA Study Identifies an Association Between the Use of Hormonal Contraceptives and Orofacial Pain and Headaches Public Deposited

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Last Modified
  • February 22, 2019
Creator
  • Fillingim, Roger
    • Other Affiliation: Department of Community Dentistry and Behavioral Science, University of Florida
  • Gaynor, Sheila
    • Affiliation: Gillings School of Global Public Health, Department of Biostatistics
  • Maixner, William
    • Affiliation: School of Dentistry, Department of Endodontics
    • Other Affiliation: Regional Center for Neurosensory Disorders
  • Bair, Eric
    • Affiliation: School of Dentistry, Department of Endodontics, Gillings School of Global Public Health, Department of Biostatistics
    • Other Affiliation: Regional Center for Neurosensory Disorders
  • Zolnoun, Denniz
    • Affiliation: School of Medicine, Department of Obstetrics and Gynecology
  • Greenspan, Joel
    • Other Affiliation: Department of Neural and Pain Sciences, University of Maryland-Baltimore
  • Slade, Gary
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
    • Other Affiliation: Regional Center for Neurosensory Disorders
  • Ohrbach, Richard
    • Other Affiliation: Department of Oral Diagnostic Sciences, University of Buffalo
  • Carey, Erin T.
    • Affiliation: School of Medicine, Department of Obstetrics and Gynecology
  • Dubner, Ron
    • Other Affiliation: Department of Neural and Pain Sciences, University of Maryland-Baltimore
Abstract
  • Introduction: • Hormone therapy has been described as a risk factor for chronic pain conditions such as low back pain and temporomandibular disorders (TMD)• Hormonal contraception (HC) may affect pain by altering the function of the endogenous opioid system and augmenting serotonin metabolism • HC has been shown to increase experimental heat and ischemic pain sensitivity in women with TMD and migraine headaches • Women using HC also demonstrate decreased pressure pain and tactile thresholds of the temporalis and masseter muscles compared to healthy women not using HC • An association between the use of HC and painful conditions such as migraine headaches and TMD has been described in previous studies although the nature of this association remains unclear • This analysis sought to determine the relationship between HC use and painful symptoms (particularly headaches and orofacial pain)
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