Function of βII-Spectrin (SPTBN1) in Skeletal Muscle Metabolism Public Deposited

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  • September 22, 2022
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  • Choi, Grace
    • Affiliation: College of Arts and Sciences, Department of Biology
    • Other Affiliation: Honors Carolina
Abstract
  • The aim of this project is to characterize the role of the cytoskeletal protein βII-spectrin in skeletal muscle (SKM) structure and metabolism. Using a novel conditional SKM-specific βII-spectrin knockout (SKM-βII-spectrin-KO) I recently validated, I will determine structural and functional consequences of βII-spectrin deficiency in SKM. Based on known functions of βII-spectrin and preliminary findings, I hypothesize that βII-spectrin is required for maintaining the structural integrity, mitochondrial content, and bioenergetic capacity of SKM fibers. Results from this study will increase our understanding of the contribution of the cytoskeleton to SKM energetics and the mechanistic basis of muscle-related deficiencies found in individuals with impaired βII-spectrin function.
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  • In Copyright
Advisor
  • Lorenzo, Damaris
    • Affiliation: School of Medicine, Department of Cell Biology and Physiology
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  • Chapel Hill, North Carolina, United States
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