Human Immunodeficiency Virus-1 Reservoir in Human Brain Myeloid Cells

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  • August 11, 2022
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  • While it is known that the reservoir of human immunodeficiency virus type-1 (HIV) resides in the memory CD4+ T cell compartment, there is an incomplete understanding of the persistence of HIV in brain myeloid cells (BMC) in the central nervous system (CNS), which may be essential to the creation of a cure of HIV in people living with HIV (PLWH). I am interested in whether BMCs harbor replication-competent HIV and its underlined molecular mechanism. I will test my hypothesis that BMCs isolated from the brains of PLWH are latently infected and harbor replication-competent HIV in the CNS with the following aim: AIM: Understand the components and molecular machinery that cause underlying HIV latency in long-lived BMCs. Through this study, I will help my lab to understand the role of HIV myeloid reservoirs in the brain in PLWH and start to understand how HIV achieves its latency in BMCs, especially long-lived brain microglia.
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