The Effect of PFAS on Breast Cancer Cell Invasiveness Public Deposited

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  • August 15, 2022
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  • Miranda Buzetta, Abel Andre
    • Affiliation: College of Arts and Sciences, Department of Biology
Abstract
  • Perfluorooctanoic acid (PFOA) is a known persistent organic pollutant and carcinogen. The stability of carbon-fluorine bonds lend to its application as a robust coating in various consumer goods and military-grade firefighting foam. This same quality allows for significant buildup in exposed soil and groundwater, leading to bioaccumulation in the bodies of living organisms. In the U.S., detectable levels of PFOA are ubiquitously present in population blood serum samples. Epidemiological studies have linked PFAS toxicity to tumorigenesis involved in liver cancer, pancreatic cancer, testicular cancer and breast cancer. The purpose of the present study is to analyze how short-term exposure to different concentrations of PFOA interact with ERɑ-positive and triple-negative breast cancer cell lines. Specifically, the study focused on the effects in epithelial to mesenchymal transition (EMT), which cancer cells undergo during the first stage of metastasis.
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