Comparative effects of non-steroidal anti-inflammatory drugs (NSAIDs) on blood pressure in patients with hypertension
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Aljadhey, Hisham, et al. Comparative Effects of Non-steroidal Anti-inflammatory Drugs (nsaids) On Blood Pressure In Patients with Hypertension. BioMed Central Ltd, 2012. https://doi.org/10.17615/m41f-r704APA
Aljadhey, H., Tu, W., Hansen, R., Blalock, S., Brater, D., & Murray, M. (2012). Comparative effects of non-steroidal anti-inflammatory drugs (NSAIDs) on blood pressure in patients with hypertension. BioMed Central Ltd. https://doi.org/10.17615/m41f-r704Chicago
Aljadhey, Hisham, Wanzhu Tu, Richard A Hansen, Susan Blalock, D Craig Brater, and Michael D Murray. 2012. Comparative Effects of Non-Steroidal Anti-Inflammatory Drugs (nsaids) On Blood Pressure In Patients with Hypertension. BioMed Central Ltd. https://doi.org/10.17615/m41f-r704- Creator
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Aljadhey, Hisham
- Other Affiliation: Medication Safety Research Chair, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
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Tu, Wanzhu
- Other Affiliation: Indiana University School of Medicine, Indianapolis, IN, USA; Regenstrief Institute, Inc, Indianapolis, IN, USA
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Hansen, Richard A
- Other Affiliation: Department of Pharmacy Care Systems, Harrison School of Pharmacy, Auburn University, Auburn, AL, USA
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Blalock, Susan
- Affiliation: Eshelman School of Pharmacy, Division of Pharmaceutical Outcomes and Policy
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Brater, D Craig
- Other Affiliation: Indiana University School of Medicine, Indianapolis, IN, USA
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Murray, Michael D
- Other Affiliation: Regenstrief Institute, Inc, Indianapolis, IN, USA; Purdue University College of Pharmacy, West Lafayette, IN, USA
- Abstract
- Abstract Background Nonsteroidal anti-inflammatory drugs (NSAIDs) may disrupt control of blood pressure in hypertensive patients and increase their risk of morbidity, mortality, and the costs of care. The objective of this study was to examine the association between incident use of NSAIDs and blood pressure in patients with hypertension. Methods We conducted a retrospective cohort study of adult hypertensive patients to determine the effects of their first prescription for NSAID on systolic blood pressure and antihypertensive drug intensification. Data were collected from an electronic medical record serving an academic general medicine practice in Indianapolis, Indiana, USA. Using propensity scores to minimize bias, we matched a cohort of 1,340 users of NSAIDs with 1,340 users of acetaminophen. Propensity score models included covariates likely to affect blood pressure or the use of NSAIDs. The study outcomes were the mean systolic blood pressure measurement after starting NSAIDs and changes in antihypertensive therapy. Results Compared to patients using acetaminophen, NSAID users had a 2 mmHg increase in systolic blood pressure (95% CI, 0.7 to 3.3). Ibuprofen was associated with a 3 mmHg increase in systolic blood pressure compared to naproxen (95% CI, 0.5 to 4.6), and a 5 mmHg increase compared to celecoxib (95% CI, 0.4 to 10). The systolic blood pressure increase was 3 mmHg in a subgroup of patients concomitantly prescribed angiotensin converting enzyme inhibitors or calcium channel blockers and 6 mmHg among those prescribed a beta-adrenergic blocker. Blood pressure changes in patients prescribed diuretics or multiple antihypertensives were not statistically significant. Conclusion Compared to acetaminophen, incident use of NSAIDs, particularly ibuprofen, is associated with a small increase in systolic blood pressure in hypertensive patients. Effects in patients prescribed diuretics or multiple antihypertensives are negligible.
- Date of publication
- October 24, 2012
- DOI
- Identifier
- Resource type
- Article
- Rights statement
- In Copyright
- Rights holder
- Hisham Aljadhey et al.; licensee BioMed Central Ltd.
- License
- Journal title
- BMC Cardiovascular Disorders
- Journal volume
- 12
- Journal issue
- 1
- Page start
- 93
- Language
- English
- Is the article or chapter peer-reviewed?
- Yes
- ISSN
- 1471-2261
- Bibliographic citation
- BMC Cardiovascular Disorders. 2012 Oct 24;12(1):93
- Publisher
- BioMed Central Ltd
- Access right
- Open Access
- Date uploaded
- November 20, 2012
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