Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype

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Creator
  • Lobenhofer, Edward K
    • Other Affiliation: Cogenics, a Division of Clinical Data, Inc.
  • Auman, J Todd
    • Affiliation: Eshelman School of Pharmacy, Center of Pharmacogenomics and Individualized Therapy
    • Other Affiliation: NIEHS Microarray Group, National Institute of Environmental Health Sciences, National Institutes of Health
  • Blackshear, Pamela E
    • Other Affiliation: Integrated Laboratory Systems, Inc.
  • Boorman, Gary A
    • Other Affiliation: National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health
  • Bushel, Pierre R
    • Other Affiliation: Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health
  • Cunningham, Michael L
    • Other Affiliation: National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health
  • Fostel, Jennifer M
    • Other Affiliation: National Center for Toxicogenomics; Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences
  • Gerrish, Kevin
    • Other Affiliation: NIEHS Microarray Group, National Institute of Environmental Health Sciences, National Institutes of Health
  • Heinloth, Alexandra N
    • Other Affiliation: NIEHS Microarray Group, National Institute of Environmental Health Sciences, National Institutes of Health
  • Irwin, Richard D
    • Other Affiliation: National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health
  • Malarkey, David E
    • Other Affiliation: Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, National Institutes of Health
  • Merrick, B Alex
    • Other Affiliation: Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health
  • Sieber, Stella O
    • Other Affiliation: NIEHS Microarray Group, National Institute of Environmental Health Sciences, National Institutes of Health
  • Tucker, Charles J
    • Other Affiliation: NIEHS Microarray Group, National Institute of Environmental Health Sciences, National Institutes of Health
  • Ward, Sandra M
    • Other Affiliation: Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, National Institutes of Health
  • Wilson, Ralph E
    • Other Affiliation: Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, National Institutes of Health
  • Hurban, Patrick
    • Other Affiliation: Cogenics, a Division of Clinical Data, Inc.
  • Tennant, Raymond W
    • Other Affiliation: Cancer Biology Group, National Institute of Environmental Health Sciences, National Institutes of Health
  • Paules, Richard S
    • Other Affiliation: Environmental Stress and Cancer Group, National Institute of Environmental Health Sciences, National Institutes of Health
Abstract
  • This report details the standardized experimental design and the different data streams that were collected (histopathology, clinical chemistry, hematology and gene expression from the target tissue (liver) and a bio-available tissue (blood)) after treatment with eight known hepatotoxicants (at multiple time points and doses with multiple biological replicates). The results of the study demonstrate the classification of histopathological differences, likely reflecting differences in mechanisms of cell-specific toxicity, using either liver tissue or blood transcriptomic data.
Date of publication
DOI
Identifier
Resource type
  • Article
Rights statement
  • In Copyright
Rights holder
  • Edward K Lobenhofer et al.; licensee BioMed Central Ltd.
License
Journal title
  • Genome Biology
Journal volume
  • 9
Journal issue
  • 6
Page start
  • R100
Language
  • English
Is the article or chapter peer-reviewed?
  • Yes
ISSN
  • 1465-6906
Bibliographic citation
  • Genome Biology. 2008 Jun 20;9(6):R100
Publisher
  • BioMed Central Ltd
Access right
  • Open Access
Date uploaded
  • August 24, 2012

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file details gb-2008-9-6-r100.pdf 2019-05-06 Public Download
file details Histopathological scores as well as the clinical chemistry and hematology data that were generated for each animal in this project. 2019-05-06 Public Download
file details gb-2008-9-6-r100.xml 2019-05-06 Public Download
file details Enrichment p-values that resulted from performing a GO enrichment analysis on the list of classifiers for each dose_time_tissue group. GO categories must have had at least five associated genes measured on the microarray in order to be included. 2019-05-06 Public Download
file details Scoring method used for the histopathological observations made in this project. 2019-05-06 Public Download
file details Agilent probe identifiers that resulted from the SVM analyses detailed in the Results section. 2019-05-06 Public Download
file details Observations and measurements made during the in-life portion of the project. 2019-05-06 Public Download