Immunological and short-term brain volume changes in relapsing forms of multiple sclerosis treated with interferon beta-1a subcutaneously three times weekly: an open-label two-arm trial
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Dwyer, Michael G, et al. Immunological and Short-term Brain Volume Changes In Relapsing Forms of Multiple Sclerosis Treated with Interferon Beta-1a Subcutaneously Three Times Weekly: an Open-label Two-arm Trial. BioMed Central, 2015. https://doi.org/10.17615/04p6-g937APA
Dwyer, M., Zivadinov, R., Tao, Y., Zhang, X., Kennedy, C., Bergsland, N., Ramasamy, D., Durfee, J., Hojnacki, D., Weinstock Guttman, B., Hayward, B., Dangond, F., & Markovic Plese, S. (2015). Immunological and short-term brain volume changes in relapsing forms of multiple sclerosis treated with interferon beta-1a subcutaneously three times weekly: an open-label two-arm trial. BioMed Central. https://doi.org/10.17615/04p6-g937Chicago
Dwyer, Michael G, Robert Zivadinov, Yazhong Tao, Xin Zhang, Cheryl Kennedy, Niels Bergsland, Deepa P Ramasamy et al. 2015. Immunological and Short-Term Brain Volume Changes In Relapsing Forms of Multiple Sclerosis Treated with Interferon Beta-1a Subcutaneously Three Times Weekly: an Open-Label Two-Arm Trial. BioMed Central. https://doi.org/10.17615/04p6-g937- Creator
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Dwyer, Michael G
- Other Affiliation: Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, 100 High St, Buffalo, NY 14203, USA; Department of Biomedical Informatics, State University of New York at Buffalo, 100 High St, Buffalo, NY 14203, USA
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Zivadinov, Robert
- Other Affiliation: Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, 100 High St, Buffalo, NY 14203, USA; Department of Neurology, State University of New York at Buffalo, 100 High St, Buffalo, NY 14203, USA
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Tao, Yazhong
- Affiliation: School of Medicine, Department of Neurology, Department of Microbiology and Immunology
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Zhang, Xin
- Affiliation: School of Medicine, Department of Neurology, Department of Microbiology and Immunology
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Kennedy, Cheryl
- Other Affiliation: Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, 100 High St, Buffalo, NY 14203, USA
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Bergsland, Niels
- Other Affiliation: Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, 100 High St, Buffalo, NY 14203, USA
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Ramasamy, Deepa P
- Other Affiliation: Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, 100 High St, Buffalo, NY 14203, USA
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Durfee, Jackie
- Other Affiliation: Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, 100 High St, Buffalo, NY 14203, USA
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Hojnacki, David
- Other Affiliation: Department of Neurology, State University of New York at Buffalo, 100 High St, Buffalo, NY 14203, USA
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Weinstock-Guttman, Bianca
- Other Affiliation: Department of Neurology, State University of New York at Buffalo, 100 High St, Buffalo, NY 14203, USA
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Hayward, Brooke
- Other Affiliation: EMD Serono, Inc., One Technology Pl, Rockland, MA 02370, USA
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Dangond, Fernando
- Other Affiliation: EMD Serono, Inc., One Technology Pl, Rockland, MA 02370, USA
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Markovic-Plese, Silva
- Affiliation: School of Medicine, Department of Neurology, Department of Microbiology and Immunology
- Abstract
- Abstract Background Brain volume atrophy is observed in relapsing–remitting multiple sclerosis (RRMS). Methods Brain volume changes were evaluated in 23 patients with RRMS treated with interferon β-1a 44 μg given subcutaneously (SC) three times a week (tiw) and 15 healthy controls. Percentages of whole brain and tissue-specific volume change were measured from baseline (0 months) to 3 months, from 3 to 6 months, and from baseline to 6 months using SIENAX Multi Time Point (SX-MTP) algorithms. Immunological status of patients was also determined and correlations between subsets of T cells and changes in brain volume were assessed. Results Interferon β-1a 44 μg SC tiw in 23 patients with RRMS resulted in significant reductions in whole brain and gray matter tissue volume early in the treatment course (baseline to 3 months; mean change; –0.95 %; P = 0.030, –1.52 %; P = 0.004, respectively), suggesting a short-term treatment-induced pseudoatrophy effect. From baseline to 6 months, there were significant correlations observed between decreased T- cell expression of IL-17 F and decreased whole brain and brain tissue-specific volume. Conclusions These findings are consistent with the interpretation of the pseudoatrophy effect as resolution of inflammation following treatment initiation with interferon β-1a 44 μg SC tiw, rather than disease-related tissue loss. Trial registration ClinicalTrials.gov; NCT01085318
- Date of publication
- November 11, 2015
- DOI
- Identifier
- Resource type
- Article
- Rights statement
- In Copyright
- Rights holder
- Dwyer et al.
- Language
- English
- Bibliographic citation
- BMC Neurology. 2015 Nov 11;15(1):232
- Publisher
- BioMed Central
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