Immunological and short-term brain volume changes in relapsing forms of multiple sclerosis treated with interferon beta-1a subcutaneously three times weekly: an open-label two-arm trial

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  • Dwyer, Michael G
    • Other Affiliation: Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, 100 High St, Buffalo, NY 14203, USA; Department of Biomedical Informatics, State University of New York at Buffalo, 100 High St, Buffalo, NY 14203, USA
  • Zivadinov, Robert
    • Other Affiliation: Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, 100 High St, Buffalo, NY 14203, USA; Department of Neurology, State University of New York at Buffalo, 100 High St, Buffalo, NY 14203, USA
  • Tao, Yazhong
    • Affiliation: School of Medicine, Department of Neurology, Department of Microbiology and Immunology
  • Zhang, Xin
    • Affiliation: School of Medicine, Department of Neurology, Department of Microbiology and Immunology
  • Kennedy, Cheryl
    • Other Affiliation: Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, 100 High St, Buffalo, NY 14203, USA
  • Bergsland, Niels
    • Other Affiliation: Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, 100 High St, Buffalo, NY 14203, USA
  • Ramasamy, Deepa P
    • Other Affiliation: Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, 100 High St, Buffalo, NY 14203, USA
  • Durfee, Jackie
    • Other Affiliation: Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, 100 High St, Buffalo, NY 14203, USA
  • Hojnacki, David
    • Other Affiliation: Department of Neurology, State University of New York at Buffalo, 100 High St, Buffalo, NY 14203, USA
  • Weinstock-Guttman, Bianca
    • Other Affiliation: Department of Neurology, State University of New York at Buffalo, 100 High St, Buffalo, NY 14203, USA
  • Hayward, Brooke
    • Other Affiliation: EMD Serono, Inc., One Technology Pl, Rockland, MA 02370, USA
  • Dangond, Fernando
    • Other Affiliation: EMD Serono, Inc., One Technology Pl, Rockland, MA 02370, USA
  • Markovic-Plese, Silva
    • Affiliation: School of Medicine, Department of Neurology, Department of Microbiology and Immunology
Abstract
  • Abstract Background Brain volume atrophy is observed in relapsing–remitting multiple sclerosis (RRMS). Methods Brain volume changes were evaluated in 23 patients with RRMS treated with interferon β-1a 44 μg given subcutaneously (SC) three times a week (tiw) and 15 healthy controls. Percentages of whole brain and tissue-specific volume change were measured from baseline (0 months) to 3 months, from 3 to 6 months, and from baseline to 6 months using SIENAX Multi Time Point (SX-MTP) algorithms. Immunological status of patients was also determined and correlations between subsets of T cells and changes in brain volume were assessed. Results Interferon β-1a 44 μg SC tiw in 23 patients with RRMS resulted in significant reductions in whole brain and gray matter tissue volume early in the treatment course (baseline to 3 months; mean change; –0.95 %; P = 0.030, –1.52 %; P = 0.004, respectively), suggesting a short-term treatment-induced pseudoatrophy effect. From baseline to 6 months, there were significant correlations observed between decreased T- cell expression of IL-17 F and decreased whole brain and brain tissue-specific volume. Conclusions These findings are consistent with the interpretation of the pseudoatrophy effect as resolution of inflammation following treatment initiation with interferon β-1a 44 μg SC tiw, rather than disease-related tissue loss. Trial registration ClinicalTrials.gov; NCT01085318
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  • Article
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  • In Copyright
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  • Dwyer et al.
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  • English
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  • BMC Neurology. 2015 Nov 11;15(1):232
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  • BioMed Central

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