Common carotid arterial interadventitial distance (diameter) as an indicator of the damaging effects of age and atherosclerosis, a cross-sectional study of the Atherosclerosis Risk in Community Cohort Limited Access Data (ARICLAD), 1987-89
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Eigenbrodt, Marsha L, et al. Common Carotid Arterial Interadventitial Distance (diameter) As an Indicator of the Damaging Effects of Age and Atherosclerosis, a Cross-sectional Study of the Atherosclerosis Risk In Community Cohort Limited Access Data (ariclad), 1987-89. BioMed Central Ltd, 2006. https://doi.org/10.17615/5awb-sh40APA
Eigenbrodt, M., Bursac, Z., Rose, K., Couper, D., Tracy, R., Evans, G., Brancati, F., & Mehta, J. (2006). Common carotid arterial interadventitial distance (diameter) as an indicator of the damaging effects of age and atherosclerosis, a cross-sectional study of the Atherosclerosis Risk in Community Cohort Limited Access Data (ARICLAD), 1987-89. BioMed Central Ltd. https://doi.org/10.17615/5awb-sh40Chicago
Eigenbrodt, Marsha L., Zoran Bursac, Kathryn M Rose, David Couper, Richard E Tracy, Gregory W Evans, Frederick L Brancati et al. 2006. Common Carotid Arterial Interadventitial Distance (diameter) As an Indicator of the Damaging Effects of Age and Atherosclerosis, a Cross-Sectional Study of the Atherosclerosis Risk In Community Cohort Limited Access Data (ariclad), 1987-89. BioMed Central Ltd. https://doi.org/10.17615/5awb-sh40- Creator
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Eigenbrodt, Marsha L.
- Other Affiliation: Department of Epidemiology, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, USA
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Bursac, Zoran
- Other Affiliation: Department of Biostatistics, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, USA
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Rose, Kathryn M.
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Couper, David
- Affiliation: Gillings School of Global Public Health, Department of Biostatistics
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Tracy, Richard E.
- Other Affiliation: Department of Pathology, Louisiana State University Health Science Center, New Orleans, USA
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Evans, Gregory W.
- Other Affiliation: Department of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, USA
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Brancati, Frederick L.
- Other Affiliation: Departments of Medicine and Epidemiology, Johns Hopkins School of Medicine and Johns Hopkins Bloomberg School of Public Health, Baltimore, USA
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Mehta, Jawahar L.
- Other Affiliation: Departments of Internal Medicine, Physiology, and Biophysics, Director Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences, Little Rock, USA
- Abstract
- Abstract: Background: The effect of age on common carotid artery diameter is unclear for varying atherosclerosis risk levels. Methods: Cross-sectional data from the Atherosclerosis Risk in Communities Limited Access Data set were used to estimate the association of age with B-mode ultrasound common carotid artery diameter for three atherosclerosis risk levels. Based on information from clinical examinations, B-mode ultrasounds, questionnaires, blood and other tests, participants were categorized into three groups: pre-existing disease (prevalent stroke and/or coronary heart disease), high risk group (no pre-existing disease, but prevalent diabetes, hypertension, plaques/ shadowing, body mass index >= 30, current smoking, or hyperlipidemia), and a low risk group (no pre-existing disease, no plaques/shadowing, and no major elevated risk factors). Multivariable linear regression analyses modeled the common carotid artery diameter relationship with age. Results: Age was positively and significantly associated with common carotid artery diameter after risk factor adjustment in the overall sample, but age had a larger effect among persons with evidence of atherosclerosis (interaction p < 0.05). Each year of older age was associated with 0.03 mm larger diameter/year among persons with pre-existing disease, with 0.027 mm larger diameter/ year in the high risk group, but only 0.017 mm/year among the low risk group. Results were qualitatively similar using plaques/shadowing status to indicate atherosclerosis severity. Conclusion: The significant impact of age on common carotid artery diameter among low risk, middle-aged, black and white men and women suggests arterial remodelling may occur in the absence of identified risk factors. The significantly larger impact of age among persons with, compared to persons without identified atherosclerosis or its risk factors, suggests that arterial remodelling may be an indicator of exposure duration.
- Date of publication
- January 3, 2006
- DOI
- Identifier
- Resource type
- Article
- Rights statement
- In Copyright
- Rights holder
- Marsha L Eigenbrodt et al.; licensee BioMed Central Ltd.
- License
- Journal title
- Cardiovascular Ultrasound
- Journal volume
- 4
- Journal issue
- 1
- Page start
- 1
- Language
- English
- Is the article or chapter peer-reviewed?
- Yes
- ISSN
- 1476-7120
- Bibliographic citation
- Cardiovascular Ultrasound. 2006 Jan 03;4(1):1
- Publisher
- BioMed Central Ltd
- Access right
- Open Access
- Date uploaded
- September 5, 2012
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