Mechanistic Indicators of Childhood Asthma (MICA) Study: piloting an integrative design for evaluating environmental health

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  • Gallagher, Jane
    • Other Affiliation: National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, USA
  • Hudgens, Edward
    • Other Affiliation: National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, USA
  • Williams, Ann
    • Other Affiliation: National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, USA
  • Inmon, Jefferson
    • Other Affiliation: National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, USA
  • Rhoney, Scott
    • Other Affiliation: National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, USA
  • Andrews, Gina
    • Other Affiliation: National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, USA
  • Reif, David
    • Other Affiliation: National Center for Computational Toxicology, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, USA
  • Heidenfelder, Brooke
    • Other Affiliation: National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, USA
  • Neas, Lucas
    • Other Affiliation: National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, USA
  • Williams, Ronald
    • Other Affiliation: U.S. Environmental Protection Agency, National Exposure Research Laboratory, Research Triangle Park, North Carolina, 27711, USA
  • Johnson, Markey
    • Other Affiliation: National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, USA; U.S. Environmental Protection Agency, National Exposure Research Laboratory, Research Triangle Park, North Carolina, 27711, USA
  • Özkaynak, Haluk
    • Other Affiliation: U.S. Environmental Protection Agency, National Exposure Research Laboratory, Research Triangle Park, North Carolina, 27711, USA
  • Edwards, Stephen
    • Other Affiliation: National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, USA
  • Hubal, Elaine
    • Other Affiliation: National Center for Computational Toxicology, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, USA
Abstract
  • Abstract Background Asthma is a common complex disease responsible for considerable morbidity and mortality, particularly in urban minority populations. The Mechanistic Indicators of Childhood Asthma study was designed to pilot an integrative approach in children's health research. The study incorporates exposure metrics, internal dose measures, and clinical indicators to decipher the biological complexity inherent in diseases such as asthma and cardiovascular disease with etiology related to gene-environment interactions. Methods/Design 205 non-asthmatic and asthmatic children, (9-12 years of age) from Detroit, Michigan were recruited. The study includes environmental measures (indoor and outdoor air, vacuum dust), biomarkers of exposure (cotinine, metals, total and allergen specific Immunoglobulin E, polycyclic aromatic hydrocarbons, volatile organic carbon metabolites) and clinical indicators of health outcome (immunological, cardiovascular and respiratory). In addition, blood gene expression and candidate SNP analyses were conducted. Discussion Based on an integrative design, the MICA study provides an opportunity to evaluate complex relationships between environmental factors, physiological biomarkers, genetic susceptibility and health outcomes. Project approval IRB Number 05-EPA-2637: The human subjects' research protocol was reviewed by the Institutional Review Board (IRB) of the University of North Carolina; the IRB of Westat, Inc., the IRB of the Henry Ford Health System; and EPA's Human Subjects' Research Review Official.
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  • Article
Rights statement
  • In Copyright
Rights holder
  • Jane Gallagher et al.; licensee BioMed Central Ltd.
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Journal title
  • BMC Public Health
Journal volume
  • 11
Journal issue
  • 1
Page start
  • 344
Language
  • English
Is the article or chapter peer-reviewed?
  • Yes
ISSN
  • 1471-2458
Bibliographic citation
  • BMC Public Health. 2011 May 19;11(1):344
Publisher
  • BioMed Central Ltd
Access right
  • Open Access
Date uploaded
  • August 23, 2012

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file details Table 1 The exposure, biomarkers, clinical indicators, and genetic variables measured in MICA. 2019-05-06 Public Download